谢小冬

职  务:英国威廉希尔唯一官网遗传医学中心主任

职  称:教授、博士生导师

电子邮箱:xdxie@lzu.edu.cn

科研方向:人类分子流行病学研究、基因组医学和转化医学研究、群体遗传学研究及生物工程方面的应用研究。

谢小冬 ,男,回族1969年1月生,博士,中共党员,教授,博士生导师。英国威廉希尔唯一官网遗传学研究所所长,英国威廉希尔唯一官网遗传医学中心主任;2005年入选教育部新世纪优秀人才支持计划,2014年荣获第六届“全国优秀科技工作者”称号;英国Leicester 大学遗传系兼职博士导师;国际基因变异组计划(HVP)联合国家顾问理事会(ICCAC)理事,国际基因变异组计划(HVP)中国区专家委员会常务委员,中国优生科学协会第六届理事会常务理事,中国优生科学协会基因诊断学分会副会长,中国遗传学会第九届理事会理事,中国遗传学会人类和医学遗传委员会委员,中国遗传学会产业促进委员会委员,中华医学会医学遗传学会委员会委员,第三届中国人类遗传资源管理专家组专家,甘肃省医学遗传学会主任委员,甘肃省遗传学会副理事长,甘肃省健康管理研究会副会长,甘肃省生物工程学会副会长,甘肃省检验与诊断技术专业委员会副主任委员,甘肃省科技基础条件平台建设专家委员会专家,甘肃省心脏病研究所副所长、甘肃省出生缺陷防控研究重点实验室培育基地学术委员会主任,甘肃省功能基因组与分子诊断重点实验室学术委员会副主任,甘肃省空间辐射生物学重点实验室学术委员会副主任,甘肃省新药临床前研究重点实验室学术指导与专家决策小组专家,甘肃省证据科学技术研究与应用重点实验室学术委员会专家,云南省医学遗传和生物医药协同创新中心副理事长,中央民族大学中国少数民族传统医学研究国家民委—教育部重点实验室学术委员会成员,Association of Cambridge Studies理事,Journal of Cambridge Studies副主编,《中国优生与遗传杂志》杂志副主编,《中华医学遗传学》杂志编委,《遗传》杂志编委,《英国威廉希尔唯一官网学报》(医学版)编委,SCI杂志Molecular Biology Reports、Molecular Carcinogenesis,Rheumatology,Human Immunology,Molecular Diagnosis & Therapy和Journal of Genetics and Genomics审稿人。

目前主要从事西北地区和青藏高原地区主要民族的基因组医学和转化医学研究、群体遗传学研究及生物工程方面的应用研究。

主持课题情况:

自2001年起,先后主持国家自然科学基金5项,973项目分课题2项,国家国际科技合作专项1项,科技部国家科技基础平台项目3项,科技部支撑计划1项,其他省部级项目13项,校内项目3项。

1. 2016年国家自然基金“高原环境因素和环境应答基因SESN2互作对先天性心脏病易感性影响的机制研究”(31670379) 主持人;

2. 2014年云南省医学遗传和生物医药协同创新中心建设项目-少数民族遗传疾病的发病机理课题负责人;

3. 2013年国家科技支撑计划项目“藏彝走廊世居群体遗传多样性调查”(2013FY114300),子课题负责人;

4. 2013年国家自然基金“中国人群中胃癌患者5-Fu化疗敏感性相关miRNA的研究”(81272454)主持人;

5. 法国ANR(The French National Research Agency)项目“语言和基因的相关性-中国西北地区考察” (项目号:ANR-12-BSH2-0004-01)中方主持人;

6. 2011年国家国际科技合作专项项目“先天性心脏病的转化医学国际合作研究”(2011DFA33120) 主持人;

7. 2010年国家自然基金“中国人群中胃癌化疗敏感性与基因多态性的关联研究”(81071701)主持人;

8. 国家973项目《先天性心脏病形成、发展和干预的基础研究》(项目编号:2010CB529500)分课题“先天性心脏病遗传学的研究” 课题负责人 ;

9. 国家973项目《重离子束治癌关键科学技术问题》项目(项目编号:2010CB834201)子课题“重离子束治癌个体基因组敏感性差异的分子机理研究” 课题负责人;

10.2007年科技部国家科技基础平台工作重点项目“青藏高原地区人群先天性心脏病,胃癌易患性及遗传与环境交互作用研究” (项目批准号:2006DKA21301)主持人;

11.2005年国家自然科学基金项目“中国河西走廊地区骊靬人的群体遗传学研究”(项目批准号:30571014) 主持人;

12.2005年教育部“中华民族群体遗传数据整合共享平台”(项目编号:505015)英国威廉希尔唯一官网项目建设负责人;

13.2004年国家自然科学基金项目“广谱抗菌转基因甘草品种的建立”(项目批准号:30371745),项目主持人;

14.2004年科技部“中国人口遗传资源共享平台建设项目”中国特殊地理环境遗传资源研究(项目批准号:2004DKA30490)课题负责人;

15.2003年甘肃省省长专项基金“利用新型抗病毒蛋白生产抗SARS药物的研究”(GS033-A43-008),项目主持人;

近期发表的有关论文:

自2000年起,发表论文96篇,其中SCI核心期刊论文52篇,CSCD刊物论文37篇,全国社科类权威刊物论文1篇,全国社科类核心刊物论文3篇,国际会议论文3篇:

1. Jinduo Zhang,Gang Su,Zengwei Tang,Li Wang,Wenkang Fu,Sheng Zhao,Yongjiang Ba,Bing Bai,Ping Yue,Yanyan Lin,Zhongtian Bai, Jinjing Hu,Wenbo Meng*,Liang Qiao,Xun Li,Xiaodong Xie* Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3. Front. Physiol., 2018(3): doi.org/10.3389/fphys.2018.00234

2. Yi Li, Zhengyi Zhang, Xiangnan Zhou, Rui Li, Yan Cheng, Bo Shang, Yu Han, Bin Liu, Xiaodong Xie*(2017) Histone Deacetylase 1 Inhibition Protects Against Hypoxia-Induced Swelling in H9c2 Cardiomyocytes Through Regulating Cell Stiffness. Circulation Journal, doi.org/10.1253/circj.CJ-17-0022

3. XieHan-hui, LiJiong, Pei-qiangLi, Zhang An-an, LiYi, Wang Yan-zhen, Xie Ding-xiong, Xie Xiao-dong* (2017) A Genetic Variant in a Homocysteine Metabolic Gene that Increases the Risk of Congenital Cardiac Septal Defects in Han Chinese Populations. IUBMB Life, 69(9):700–705

4. Lu Guo, Caixia Zhang, Jinghong Zhu, Yuqin Yang, Jianfa Lan, Gang Su, Xiaodong Xie* (2016) Proteomic identification of predictive tissue biomarkers of sensitive to neoadjuvant chemotherapy in squamous cervical cancer. Life Sciences, 151(4): 102-108

5. Zheng-Yi Zhang, Yi Li, Rui Li, An-An Zhang, Bo Shang, Jing Yu, Xiao-Dong Xie (2016) Tetrahydrobiopterin Protects against Radiation?induced Growth Inhibition in H9c2 Cardiomyocytes. Chinese Medical Journal, 129 (11): 2733-2740

6. Ting Ji, Xiao-dong Xie*, Chen Tian, Yun-cong Wang, Han Liu, Jin-chao Gu, Meng-dan Song, Xiao-juan Yang (2016) Peertechz Journal of Biological Research and Development, 1: 014-017

7. Lu Guo, Hua Wu, Jinghong Zhu, Caixia Zhang, Jianxiu Ma, Jianfa Lan, Xiaodong Xie* (2015) Genetic variations in the PI3K/AKT pathway predict platinum-based neoadjuvant chemotherapeutic sensitivity in squamous cervical cancer. Life Sciences, 143:217-224, DOI:10.1016/j.lfs.2015.11.011

8. Hua Wu, Yuan-hui Gu, Li Wei, Tian-kang Guo, Yong Zhao, Gang Su, Jiong Li, Xiao-dong Xie*. (2015) Association of Romo1 gene genetic polymorphisms with risk of gastric cancer in Northwestern Chinese population. Pathol. Oncol. Res, 21:581-587

9. Zhenchang Zhang, Gang Su, Jia Guo, Jiong Li, Hua Wu, Xiaodong Xie*.(2015) Pooled Genetic Analysis Reveals an Association of SNPs of Only a Few Genes with Risk Predisposition to Ischemic Stroke in a Chinese Population. IUBMB Life, 67(3):170-174

10. Zhenchang Zhang, Jia Guo, Gang Su, Jiong Li, Hua Wu, Xiaodong Xie*.(2014) Evaluation of the Quality of Guidelines for Myasthenia Gravis with the AGREE II Instrument. PLos one, 9(11): 1-8 e111796

11. Gang Huang, Zhong-Feng Dang, Ya-Mei Dang, Wei Cai, Yuan Li, Yi-Rong Chen, Xiao-Dong Xie*. (2014) Expression and Underlying Roles of IGFBP-3 in Paclitaxel- Treated Gastric Cancer Sgc-7901 Cells. Asian Pacific Journal of Cancer Prevention, 15(14): 5741-5745

12. Jinpeng He, Junrui Hua, Nan Ding, Shuai Xu, Rui Sun, Guangming Zhou, Xiaodong Xie*, Jufang Wang* (2014) Modulation of microRNAs by ionizing radiation in human gastric cancer. ONCOLOGY REPORTS 32: 787-793

13. Dan Xu, Xin Zhao, Yi Li, Yinli JI, Jiangyan Zhang, Jufang Wang, Xiaodong Xie,* Guangming Zhou*. (2014) The combined effects of X-ray radiation and hindlimb suspension on bone loss. Journal of Radiation Research, doi: 10.1093/jrr/rru014

14. Xin Zhao, Dan Xu, Yi Li, Jiangyan Zhang, Tingting Liu, Yinli Ji, Jufang Wang, Guangming Zhou, Xiaodong Xie*. (2014) MicroRNAs regulate bone metabolism. J Bone Miner Metab, 32(3):221-231, DOI 10.1007/s00774-013-0537-7

15. Yong-Qi Liu, Yi Li, Jie Qin, Qian Wang, Ya-Li She, Ya-Li Luo, Jian- Xin He, Jing-Ya Li, Xiao-Dong Xie* (2014) Effect of Matrine Against the Proliferation of Human Lung Cancer Cell by Inducing Apoptosis and Changing on Mirna Expression Profiles. Asian Pacific Journal of Cancer Prevention, 15(5): 2169-2177, DOI: http://dx.doi.org/10.7314

16. Hua Pan, Jianfa Lan, Xin Luo, Jun Gao, Xiaodong Xie*, Hongyu Guo (2014)Biological properties of gadolinium diethylenetriamine pentaacetic acid and PKH26-labeled human umbilical cord mesenchymal stem Cells. Cytotherapy, 16(1): 74-83, http://dx.doi.org/10.1016/j.jcyt.2013.05.015

17. Dang Ya-Mei, Huang Gang, Chen Yi-Rong, Dang Zhong-Feng, Chen Cheng, Liu Feng-Lei, Guo Ying-Fang, Xie Xiao-Dong (2014) Sulforaphane Inhibits the Proliferation of the BIU87 Bladder Cancer Cell Line via IGFBP-3 Elevation. Asian Pacific Journal of Cancer Prevention, 15(4):1517-1520

18. H-Y Zhang, L Feng, H Wu, X-D Xie* (2013) The association of IL-6 and IL-6R gene polymorphisms with chronic periodontitis in a Chinese population. Oral Diseases , 20(1):69-75

19. Zhen-Chang Zhang, Gang Su, Jiong Li, Hua Wu, Xiao-Dong Xie*(2013) Two new neuroprotective phenolic compounds from Gastrodia elata. Journal of Asian Natural Products Research. DOI:10.1080/10286020.2013.791286

20. Xiaowei Sun, Ying Meng, Tao You, Peiqiang Li, Hua Wu, Ming Yu, Xiaodong Xie* (2013)Association of growth/differentiation factor 1 gene polymorphisms with the risk of congenital heart disease in the Chinese Han population. Molecular Biology Reports, 40(2):1291-9

21. Xinyue Liu, Tinghong Lv, Xiaodong Xie* , Jing Li, Gang Su, Hua Wu (2012)Antitumour Effect of the Sesquiterpene Chabranol on Four Human Cancer Cells by Inducing Apoptosis and Autophagy. Journal of International Medical Research, 40 (4):1644-1651

22. Ya-ling Liang, Hua Wu, Xi Shen, Pei-qiang Li, Xiao-qing Yang, Li Liang, Wei-hua Tian, Li-feng Zhang, Xiao-dong Xie*. (2012) Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis. Molecular Biology Reports, 39(9):8873-8882. DOI : 10.1007/s11033 -012-1754-1

23. Sun, Lei, Cheng, Longfei, Dong, Hanquan, Wang, Binbin, Huang, Guoying, Li, Zhongzhi, Xie, Xiaodong, Shen, Adong, Li, Xiaotian, Wang, Jing, *Li, Hui, Ma, Xu. (2012)Novel Mutations of NODAL Gene in Chinese Patients with Congenital Heart Disease. Genetic Testing and Molecular Biomarkers,16(4):306-309 DOI:10.1089/gtmb.2011.0101

24. Xi Shen, Rui-Min Liu, Lan Yang, Hua Wu, Pei-Qiang Li, Ya-Ling Liang, Xiao-Dong Xie*, Ting Yao, Ting-Ting Zhang, Min Yu(2011) The CRISPLD2 gene is involved in cleft lip and/or cleft palate in a Chinese population, Birth Defects Research (Part A): Clinical and Molecular Teratology, 91(10):918-924. DOI: 10.1002/bdra.20840

25. Ya-ling Liang, Hua Wu, Pei-qiang Li, Xiao-dong Xie*, Xi Shen, Xiao-qing Yang, Xuan Cheng, Li Liang. (2011) Signal transducer and activator of transcription 4 gene polymorphisms associated with rheumatoid arthritis in Northwestern Chinese Han population, Life Sci, 89(5-6):171-175. DOI:10.1016/j.lfs.2011.05.012

26. Li Wei,,Yong Zhao, Tian-kang Guo, Pei-qiang Li, Hua Wu, Han-bing Xie, Ke-jun Ma, Feng Gao, Xiao-dong Xie * (2011)Association of mtDNA D-Loop polymorphisms with risk of gastric cancer in Chinese population. Pathology & Oncology Research,17(3):735-742

27. Ting Yao, Lan Yang, Pei-qiang Li, Hua Wu, Han-bing Xie, Xi Shen, Xiao-dong Xie * (2011) Association of Wnt3A gene variants with non-syndromic cleft lip with or without cleft palate in Chinese population. Archives of Oral Biology,56:73-78

28. Jing Wang, Qiuhong Chen, Lin Wang, Sirui Zhou, Longfei Cheng, XiaoDong Xie, Guoying Huang, Binbin Wang, Xu Ma (2011) Identifying novel mutations of NKX2-5 congenital heart disease patients of Chinese Minority Groups. Int J Cardiol. 148:102-127

29. Zhi Cheng,Jing Wang, Dongmei Su,Hong Pan,Guoying Huang, Xiaotian Li,Zhongzhi Li,Adong Shen ,Xiaodong Xie,Binbin Wang,Xu Ma(2011)Two novel mutations of the IRX4 gene in patients with congenital heart disease. Hum Genet. DOI 10.1007/s00439-011-0996-7

30. Hua Wu, Li-Hua Yang, Ji Zuo, Ya-Ling Liang, Pei-Qiang Li, Wen Liu, Xiao-Dong Xie *(2010) Fc receptor–like 3 gene polymorphisms confer susceptibility to rheumatoid arthritis in a Chinese population. Human Immunology,71(12):1203-1208

31. Jing Wang, XiaoDong Xie, Sirui Zhou, Guoying Huang, Xiaojing Ma, Peisu Suo, Shiyi Zhou, Binbin Wang, Xu Ma(2010) The study of copy number variations in the regions of NOTCH1 among Chinese VSD and TOF patients. Int J Cardiol. Doi: 10.1016/j.ijcard.2010.04.029

32. He XD, Guo ZH, Tian JH, Yang KH, Xie XD (2010)Whether drainage should be used after surgery for breast cancer? A systematic review of randomized controlled trials. Med Oncol. 28:S22-S30

33. Wang B, Wen Q, Xie X, Liu S, Liu M, Tao Y, Li Z, Suo P, Shen A, Wang J, Ma X (2009) Mutation analysis of Connexon43 gene in Chinese patients with congenital heart defects. Int J Cardiol. Doi:10.1016/j.ijcard.2009.06.026

34. Wang B, Li L, Xie X, Wang J, Yan J, Mu Y, Ma X (2009) Genetic variation of SAL-Like 4 (SALL4) in ventricular septal defect. Int J Cardiol. Doi:10.1016/j.ijcard.2009.05.067

35. Wang B, Wang J, Liu S, Han X, Xie X, Tao Y, Yan J, Ma X (2009) CFC1 mutations in Chinese children with congenital heart disease. Int J Cardiol. Doi:10.1016/j.ijcard.2009.07.034

36. Wang B, Yan J, Mi R, Zhou S, Xie X, Wang J, Ma X (2009) Forkhead box H1 (FOXH1) sequence variants in ventricular septal defect. Int J Cardiol. Doi:10.1016/j.ijcard.2009.05.030

37. Wang B, Yan J, Peng Z, Wang J, Liu S, Xie X, Ma X (2009) Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. Int J Cardiol. doi:10.1016/j.ijcard.2009.08.046

38. Binbin Wang, Shiyi Zhou, Qiuhong Chen, XiaoDong Xie, Guoying Huang, Jing Wang, Sirui Zhoua, Xu Ma. (2009) Hairy-related transcription factor 2 is not potentially related to congenital heart disease in Chinese patients. Int J Cardiol. Doi:10.1016/j.ijcard.2009.12.013.

39. Mian Zhao,Qing-Peng Kong, Hua-Wei Wang, Min-Sheng Peng,Xiao-Dong Xie, Wen-Zhi Wang, Jiayang,Jian-Guo Duan,Ming-Cui Cai, Shi-Neng Zhao, Cidanpingcuo, Yuan-Quan Tui, Shi-Fang Wu, Yong-Gang Yao, Hans-Jürgen Bandelt, Ya-Ping Zhang*(2009)Mitochondrial Genome Evidence Reveals Successful Late Paleolithic Settlement on Tibetan Plateau. PNAS, 106: 21230-21235

40. Ruixia Zhou, Daqun Yang, Hua Zhang, Weiping Yu, Lizhe An, Xilong Wang, Hong Li, Jiujin Xu, Xiaodong Xie*. (2008) Origin and evolution of two Yugur sub-clans in Northwest China: a case study in paternal genetic landscape. Annals of Human Biology, 35, (2) :198 - 211

41.Ju-xiang Liu, Jing Liu, Pei-qiang Li, Xiao-dong Xie*, Qian Guo, Li-min Tian, Xiao-qin Ma , Ji-ping Zhang, Jia Liu, Jing-yuan Gao(2008)Association of sterol regulatory element-binding proteins-1c gene polymorphism with type 2 diabtets mellitus, insulin resistance and blood lipid levels in Chinese population. Diabetes Research and Clinical Practice, 82(10): 42-47

42.Jing Liu, Jing-yuan Gao, Ji-ping Zhang, Pei-qiang Li, Ju-xiang Liu, Jia Liu, Xiao-dong Xie*(2008)Evaluation of the association between retinal binding protein 4 polymorphisms and type 2 diabetes in Chinese by DHPLC. Endocrine, 34(1-3): 23-28

43.Sun Litao,Zhou Zhongwei,Xie Xiaodong*,Bao Shilai(2008)Purification and characterization of catalytically active human PRMT5 in Escherichia coli. Progress in Biochemistry and Biophysics,35(7): 801-806

44. Zhou Ruixia, An Lizhe, Wang Xilong, Wang Xunling, Shao Wei, Lin Gonghua, Yu Weiping,Yi Lin, Xu Shijian, Xu Jiujin, Xie Xiaodong*. (2007) Testing hypothesis of ancient Roman soldier origin of Liqian people in Northwest China: a Y chromosome perspective. Journal of Human Genetics,52:584-591

45. You Chongge, Li Jianfeng; Xie Xiao-Dong*, Zhu Yan; Li Peiqiang; Chen Yirong. (2007) Association of Interleukin-1 Genetic Polymorphism with risk of Rheumatoid Arthritis in Chinese Population. Clinical Chemistry and Laboratory Medicine,45(8):968-971

46. Z. Li ,W. Yu, X. Xie*, P. Li, G. Tiankang, W. Zhang, L. An, X. Wang. (2007) Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population. Clin Exp Med 7(3):98-101

47. C-G You,Y-S Yin, X-D Xie, J Ju, Z-P Wang, Y-R Chen. Sex Influences on the Penetrance of IL-1B and IL-1RN Genotypes for Rheumatoid Arthritis in the Chinese Population. (2007) Journal of International Medical Research, 35 (3):323-328

48. TK Guo, XH Zhao, XD Xie*, ZH Chen, CS Zhou, LL Wei , H Zhang. (2007) The Anti-proliferative Effects of Recombinant Human Lysozyme on Human Gastric Cancer Cells. Journal of International Medical Research, 35 (3):353-360

49. L Yi, YH Gu, XL Wang, LZ An, XD Xie*, W Shao, LY Ma, JR Fang, YD An, F Wang, DL Zhang. (2006) Association of ACE, ACE2 and UTS2 Polymorphisms with Essential Hypertension in Han and Dongxiang Populations from Northwestern China. Journal of International Medical Research, 34 (3):272-283

50. WH Zhang, XL Wang, J Zhou, LZ An, XD Xie*. (2005) Association of interleukin-1B (IL-1B) gene polymorphisms with risk of gastric cancer in Chinese population. Cytokine.30(6):378-381

51. Yajun Yang, Xiaodong Xie, Xunling Wang, Yanhong Liu; Ruixia Zhou; Weihua Zhang; Jiujin Xu; Lizhe An (2005) Allele Frequency Distribution at Seven Y-Chromosomal STR Loci Among Five Ethnic Groups from Northwest China. J Forensic Sci. 50(3):734-736

52. Xie Xiaodong, Wang Xunling, He Xiaolin, Ren Guifang, Li Xiaolin. (2001) Tibetan population data on the PCR-based loci: D16S539, D7S820, D13S317, HUMF13A01, FESFPS, vWA, HUMTH01,TPOX, andCSF1PO. International Journal of Legal Medicine. 114(6):349-351

53. Xie Xiaodong, Wang Xunling He Xiaolin, Ren Guifang, Li Xiaolin. (2001) Population study of three STR loci-HUMTH01,TPOX,and CSF1PO in Dongxiang, Hui, and Han from Northwest China. Forensic Science International. 119(2) : 258-259;(以上均为SCI核心刊物)

近期主编的教材

医学免疫学, 2010. 4,第2版 58.9万字, 人民卫生出版社,北京, ISBN978-7-117-12648-9/R·12649

基因组导向下健康管理,(副主编),2016.5,第1版,63.7万字,北京大学医学出版社,北京,ISBN 978-7-03-048377-5

医学遗传学习题集, 2005.1,第1版,10万字, 军事医学科学院出版社,北京,ISBN 7-80121-379-3

医学微生物学习题集,2005.1 ,第1版,10万字 军事医学科学院出版社,北京,ISBN 7-80121-627-X

医学免疫学习题集,2005.1 ,第1版, 10万字 军事医学科学院出版社,北京,ISBN 7-80121-617-2

主编专著

现代生物技术概论, 2007.1,第1版, 30万字, 军事医学科学院出版社,北京, ISBN 7-80121-676-8/R·669

科研成果

获授权专利9项,申请专利12项,甘肃省新产品认证3项:

专利:

1.“一种用食品级干酪素生产速溶酪蛋白酸钙的方法” 获国家发明专利,专利号:ZL 2012 1 0268534.3,申请公布号:CN102763762A,已授权,授权公告日:2013.07.31;

2. “IL-6基因SNP位点的用途”获国家发明专利,专利号:ZL 201110412140.6,申请公布号:CN102517383A,已授权,授权公告日:2013.09.04;

3. “牦牛乳酪蛋白降血压肽的制备方法” 获国家发明专利,专利号:ZL 2012 1 0315491.X,申请公布号:CN102787155A,已授权,授权公告日:2014. 3.19;;

4.“牦牛乳酪蛋白抗氧化肽的制备方法” 获国家发明专利,专利号:ZL 2012 1 0315545.2,申请公布号:CN102787156A,已授权,授权公告日:2014. 3.19;

5.“牦牛乳酪蛋白抗凝血肽的制备方法”获国家发明专利,专利号:ZL2013 1 0313774.5,申请公布号:CN103388015A,已授权,授权公告日:2015. 2.11;

6.“适用于术后康复的牦牛乳蛋白多肽粉及其制备方法” 获国家发明专利,专利号: ZL2014 1 0031576.4,申请公布号:CN103734581A,已授权,授权公告日:2015.8.26;

7.“适用于流产后女性身体康复的牦牛蛋白多肽粉及其制备方法” 获国家发明专利,专利号: ZL2014 1 0031586.8,申请公布号:CN103750106A,已授权,授权公告日:2015.8.26;

8.“一种适用于中老年人的牦牛乳蛋白多肽营养粉及其制备方法” 获国家发明专利,专利号: ZL2014 1 0031625.4,申请公布号:CN103734582A,已授权,授权公告日:2015.8.26;

9.“一种适用于中老年人的牦牛乳酪蛋白营养粉及其制备方法” 获国家发明专利,专利号: ZL2014 1 0031634.3,申请公布号:CN103798390A,已授权,授权公告日:2015.8.28;

10.“一种分子标记物在猝死发生早期筛查中的用途” 已申报国际发明专利,专利申请号PCT/CN2015/082281

甘肃省新产品认证3项:

1. 2014年“干酪素生产中在线自动加酸技术”获得甘肃省优秀新产品新技术认证(201450-1)

2. 2015年“牦牛乳酪蛋白糖巨肽” 获得甘肃省优秀新产品新技术认证(201542)

3. 2015年“牦牛乳酪蛋白抗氧化肽” 获得甘肃省优秀新产品新技术认证(201543)

获奖情况

1. 2014年荣获第六届“全国优秀科技工作者”称号;

2. 2005年获教育部新世纪优秀人才支持计划资助(NCET-05-0885);

3. 2015年“甘肃省法庭科学实践中基于分子遗传学的集成创新研究” 获甘肃省科技进步二等奖;

4. 2015年“牦牛乳酪蛋白功能性肽生产关键技术研究与开发” 获甘肃省科技进步三等奖;

5. 2014年“甘肃省法庭科学实践中基于分子遗传学的集成创新研究” 获甘肃省高校科技进步一等奖;

6. 2014年“在线自动加酸技术在干酪素生产中的研究与应用” 获甘南州科技进步一等奖;

7. 2014年“花椰菜废弃茎叶的综合利用研究与产品开发” 获甘肃省科技进步三等奖;

8. 2013年“西北及青藏高原临床和群体遗传资源共享平台建设与创新研究”获中华医学科技奖三等奖;

9. 2013年“花椰菜废弃茎叶的综合利用研究与产品开发” 获甘肃省农牧渔业丰收奖二等奖;

10. 2012年“西北及青藏高原群体和临床遗传资源共享平台建设与应用” 获甘肃医学科技奖特等奖;

11. 2012年“西北及青藏高原群体和临床遗传资源共享平台建设与应用” 获甘肃省科技进步二等奖;

12. 2008年“类风湿关节炎相关基因NCF1单核苷酸多态性研究及临床应用” 获甘肃省科技进步三等奖;

13. 2007年“类风湿关节炎相关基因NCF1单核苷酸多态性研究及临床应用” 获甘肃省高校科技进步二等奖;

14. 2006 年“IL-B基因SNP及IL-1RN基因VNTR与中国西北人群胃癌易患性的关系研究”获得甘肃医学科技奖三等奖;

15. 2012年甘肃省《医学遗传学》省级精品课程主持人;

16. 2007年“医学生命科学的教学改革与实践”获甘肃省教学成果二等奖;